Home » The Future of Longevity and Age Reversal with Dr. David Sinclair and Peter Diamandis

The Future of Longevity and Age Reversal with Dr. David Sinclair and Peter Diamandis

In a recent episode of the “Mindsets and Moonshots” podcast, hosts Peter Diamandis and David Sinclair, two leading figures in the field of longevity and age reversal, discussed the current state of longevity therapies, the challenges they face, and the future of this exciting field[1]. The conversation was rich with insights, shedding light on the potential of these therapies to extend human lifespan and improve the quality of life.

The Current State of Longevity Therapies

David Sinclair, a renowned biologist and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, explained that some longevity therapies are already here[2]. Drugs like metformin[3] and rapamycin[4], he believes, can slow down aspects of aging. However, these are not evenly distributed or widely available, primarily because many doctors are either unaware of them or unwilling to prescribe these medicines to healthy individuals.

Sinclair’s lab is also developing new medicines. One of them, a spin-out from his lab called Metro Biotech, is working on NAD boosters for pharmaceutical use for diseases of aging[5]. This drug is currently in phase two studies and could potentially be available in two to three years.

The Challenges of Developing Longevity Therapies

Developing drugs is a complex and expensive process. The industry can spend hundreds of millions of dollars and still fail. There are high safety and efficacy standards that need to be met, thanks to the oversight of the FDA in the US and other similar organizations in different countries. This makes the process slow, but necessary, to ensure that no harmful or ineffective products reach the market.

Peter Diamandis, founder and chairman of the XPRIZE Foundation, pointed out that the FDA is an organization built around safety. They value the lives lost if they approve a drug that kills people more than the lives lost by not approving a drug. Until the science is rock solid, they will be hesitant to approve something, which requires significant capital investments and time.

The Future of Longevity Therapies

Both Diamandis and Sinclair believe that we are kicking the can down the road with longevity therapies, but that’s the point. Life is wonderful, and the more times we kick the can down the road, the more life and wonder we have. They believe that a lifespan of 150 years is achievable in many of our lifespans, but not immortality.

Diamandis and Sinclair are also working on an Age Reversal XPRIZE, a $101 million prize for a therapeutic that can reverse biological age by 20 years or more. The goal is to inspire companies, labs, and individuals to work on methods to safely reverse aging in multiple tissues and organs to rejuvenate the body and make it function better.

Personal Experiences and Perspectives

Both Diamandis and Sinclair are experimenters and consider themselves guinea pigs for many longevity therapies. They believe in trying things themselves before recommending them to others. They are also open about their experiences and the reasons behind their decisions, whether they choose to try a therapy or not.

Sinclair, for instance, is taking a molecule that he’s studying in his lab. He wants to be the first person in the world to know if there’s something wrong with this molecule because he and his father are taking it. If he sees something negative, he will be the first to tell the world to stop taking it.

Diamandis, on the other hand, has started taking rapamycin, a drug that has been shown to extend lifespan in mice[4]. He did a lot of research and talked to many physicians before deciding that the reward side was higher than the risk.


The field of longevity and age reversal is still in its early stages, but the progress made so far is promising. With the efforts of scientists like Sinclair and initiatives like the Age Reversal XPRIZE, we can look forward to a future where aging is not just slowed down, but reversed, leading to longer, healthier lives.

Age Reversal Breakthroughs, FDA Approval, and Living Forever – David Sinclair’s AMA
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