Home » Unraveling the Secrets of Longevity: A Deep Dive with Dr. David Sinclair and Dr. Mark Hyman

Unraveling the Secrets of Longevity: A Deep Dive with Dr. David Sinclair and Dr. Mark Hyman

In a thought-provoking interview, Dr. Mark Hyman sat down with Dr. David Sinclair, a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging. The conversation was a deep dive into the science of aging, the role of lifestyle habits, and the potential of certain molecules in promoting health and longevity.

The Science of Aging

Dr. Sinclair is a leading figure in the field of aging research, known for his groundbreaking work on understanding the biological processes that drive aging. In the interview, he introduces the concept of epigenetic noise, a term he uses to describe the gradual “scratching” or damage of our DNA that occurs over time. This damage, he explains, is a major contributor to the aging process and the onset of age-related diseases1.

Epigenetic noise is akin to the wear and tear that a vinyl record experiences over time. Just as the sound quality of a record deteriorates with repeated playing, our DNA accumulates damage as we age. This damage can disrupt the normal functioning of our genes, leading to cellular dysfunction and disease.

However, it’s not all doom and gloom. Dr. Sinclair explains that our bodies have built-in repair systems that can fix this damage. These repair systems, which he refers to as “longevity genes,” are capable of reversing the aging process and restoring our DNA to its original state. However, these systems become less efficient as we age, which is why the risk of disease increases with age.

The Role of Lifestyle Habits

The conversation also delves into the importance of lifestyle habits in promoting health and longevity. They discuss the benefits of regular physical activity, a balanced diet, and adequate sleep, all of which have been shown to support healthy aging.

Dr. Sinclair emphasizes the potential benefits of intermittent fasting, a dietary pattern that involves alternating periods of eating and fasting. He explains that intermittent fasting can trigger our body’s repair systems, helping to reduce epigenetic noise and slow down the aging process. They also discuss the importance of aligning our eating habits with our body’s natural circadian rhythms. Dr. Sinclair explains that our bodies are more efficient at processing food earlier in the day. Therefore, eating the majority of our calories earlier in the day can help to optimize our metabolism and support weight management2.

The Potential of Molecules in Promoting Health and Longevity

In the interview, Dr. Sinclair discusses the potential of certain molecules in promoting health and longevity. He mentions resveratrol, a compound found in grapes and red wine, which has been shown to activate the SIRT1 gene, a key player in the aging process. Resveratrol is thought to mimic the effects of calorie restriction, a dietary intervention that has been shown to extend lifespan in a variety of organisms.

Dr. Sinclair also discusses the potential of NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells that plays a crucial role in energy metabolism and maintaining proper cell function. He explains that NAD+ levels decline with age, which can lead to cellular dysfunction and contribute to the aging process. However, supplementing with NAD+ precursors, such as NMN (nicotinamide mononucleotide), can help to restore NAD+ levels and promote healthy aging3.


The conversation provides a fascinating glimpse into the science of aging and the potential of lifestyle interventions and certain molecules in promoting health and longevity. As research in this field continues to evolve, it’s clear that our daily habits and choices play a significant role in our health and lifespan.

While the quest for the fountain of youth continues, the insights provided by Dr. Sinclair and Dr. Hyman underscore the importance of maintaining a healthy lifestyle and staying abreast of the latest scientific developments in the field of aging. By doing so, we can all hope to live longer, healthier lives.


1: Sinclair, D. A. (2019). Lifespan: Why We Age—and Why We Don’t Have To. Atria Books. Link

2: Longo, V. D., & Panda, S. (2016). Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metabolism, 23(6), 1048–1059. Link

3: Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 27(3), 529–547. Link

4: Li, Y., Pan, A., Wang, D. D., Liu, X., Dhana, K., Franco, O. H., … & Hu, F. B. (2018). Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population. Circulation, 138(4), 345–355. Link

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